Salaries in St. Louis.
422 roles. One city.
Cost-of-living index: 0.90x national average. Last updated April 2026.
422 roles tracked
Highest Paying
$276,000
Chief AI Officer
Median of All Roles
$134,000
AI Localization Engineer
Entry Level
$30,000
Home Health Aide
Salary data sourced from SEC filings, H-1B Labor Condition Applications (DOL), Bureau of Labor Statistics Occupational Employment and Wage Statistics, and aggregated job postings across 50+ platforms. Ranges reflect 25th to 75th percentile for full-time positions. Cost-of-living adjustments use Bureau of Economic Analysis Regional Price Parities (2025 index). Last updated April 2026.
St. Louis, MO has a cost-of-living index of 0.90x the national average. The highest-paying role is Chief AI Officer at $276,000, while the median across all 422 roles is $134,000. St.
About the St. Louis market
St. Louis offers one of the most affordable major metro areas in the country, with a strong base in healthcare, financial services, and manufacturing. The region's anchor employers include Boeing, Centene, and Washington University's medical campus. A growing biotech and plant sciences corridor centered on the Cortex Innovation District is attracting new investment and talent.
HealthcareDefense & AerospaceFinancial ServicesPlant Sciences & BiotechManufacturing
Top 50 salaries in St. Louis
| # | Role | Median | Range |
|---|
| 1 | Chief AI Officer | $276,000 | $205,000 – $356,000 |
| 2 | Chief Data & AI Officer | $271,000 | $202,000 – $353,000 |
| 3 | SVP of AI Innovation | $262,000 | $197,000 – $344,000 |
| 4 | Chief Technology Officer | $261,000 | $194,000 – $342,000 |
| 5 | Chief Algorithm Officer | $260,000 | $195,000 – $338,000 |
| 6 | CEO | $255,000 | $185,000 – $352,000 |
| 7 | Chief Revenue Officer | $249,000 | $187,000 – $330,000 |
| 8 | Head of AI | $243,000 | $180,000 – $315,000 |
| 9 | Chief Marketing Officer | $241,000 | $181,000 – $315,000 |
| 10 | CFO | $239,000 | $179,000 – $317,000 |
| 11 | Chief Data Officer | $239,000 | $179,000 – $312,000 |
| 12 | Head of AI Research | $238,000 | $176,000 – $313,000 |
| 13 | VP of AI Engineering | $234,000 | $176,000 – $304,000 |
| 14 | Chief Product Officer | $233,000 | $173,000 – $307,000 |
| 15 | Chief Operating Officer | $232,000 | $173,000 – $309,000 |
| 16 | VP of Engineering | $229,000 | $172,000 – $300,000 |
| 17 | Head of AI Platform | $228,000 | $170,000 – $298,000 |
| 18 | Chief Human Resources Officer | $227,000 | $171,000 – $295,000 |
| 19 | VP of AI Product | $220,000 | $164,000 – $285,000 |
| 20 | Head of Applied AI | $220,000 | $164,000 – $289,000 |
| 21 | Head of AI Partnerships | $220,000 | $164,000 – $290,000 |
| 22 | VP of Product | $218,000 | $165,000 – $281,000 |
| 23 | AI Transformation Officer | $218,000 | $164,000 – $286,000 |
| 24 | VP of Product Design | $214,000 | $159,000 – $277,000 |
| 25 | VP of Marketing | $214,000 | $159,000 – $282,000 |
| 26 | Director of Generative AI | $209,000 | $158,000 – $275,000 |
| 27 | VP of Sales | $207,000 | $156,000 – $276,000 |
| 28 | Director of AI Strategy | $204,000 | $154,000 – $267,000 |
| 29 | Foundation Model Engineer | $201,000 | $150,000 – $262,000 |
| 30 | Director of Data Science | $199,000 | $153,000 – $260,000 |
| 31 | AI Financial Engineer | $197,000 | $145,000 – $253,000 |
| 32 | Multi-Agent Systems Architect | $197,000 | $145,000 – $260,000 |
| 33 | Director of Engineering | $194,000 | $150,000 – $251,000 |
| 34 | AI Program Director | $194,000 | $147,000 – $255,000 |
| 35 | AI Alignment Researcher | $192,000 | $142,000 – $255,000 |
| 36 | AI Cloud Architect | $190,000 | $144,000 – $241,000 |
| 37 | AI Compiler Engineer | $187,000 | $140,000 – $245,000 |
| 38 | AI Agent Architect | $185,000 | $140,000 – $239,000 |
| 39 | AI Systems Architect | $183,000 | $138,000 – $239,000 |
| 40 | Transformer Architecture Engineer | $183,000 | $137,000 – $240,000 |
| 41 | AI World Model Engineer | $183,000 | $135,000 – $241,000 |
| 42 | Multimodal AI Engineer | $182,000 | $136,000 – $236,000 |
| 43 | Quantum ML Researcher | $182,000 | $135,000 – $241,000 |
| 44 | AI Infrastructure Manager | $182,000 | $138,000 – $237,000 |
| 45 | AI Solutions Architect | $181,000 | $134,000 – $236,000 |
| 46 | Neuro AI Engineer | $181,000 | $134,000 – $239,000 |
| 47 | Deep Learning Engineer | $180,000 | $140,000 – $230,000 |
| 48 | Agentic Orchestrator | $180,000 | $135,000 – $234,000 |
| 49 | Director of Product | $180,000 | $140,000 – $234,000 |
| 50 | Multimodal AI Researcher | $180,000 | $134,000 – $239,000 |
Tax considerations
Missouri's top income tax rate is about 4.8%, and St. Louis City adds a 1% earnings tax. The low base cost of living means your after tax salary still stretches further than in most metros.
Negotiating in St. Louis
Emphasize your willingness to work in person at Cortex or the BJC campus. St. Louis employers offer higher packages for candidates who commit to the local innovation hubs.
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