Biotech Software Engineer.
Philadelphia.
$155,000
median salary, 9% above the national average
$121,000 to $201,000. Last updated April 2026.
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Data points to own the conversation.
The median Biotech Software Engineer salary in Philadelphia is $155,000, 9% above the national average. Entry level starts near $121,000. Experienced professionals push past $201,000. Philadelphia combines a robust healthcare and life sciences sector with established finance and higher education institutions. That spread is your negotiation window.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $139,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$101,000
to $124,000
Mid (3-5 yrs)
$132,000
to $163,000
Senior (6-9 yrs)
$171,000
to $202,000
Lead (10+ yrs)
$194,000
to $240,000
Salary trend
+7% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $39,000 to the total package.
Base
$155,000
Equity
$22,000
Bonus
$14,000
Signing
$3,000
Estimated total: $194,000
How Philadelphia compares
Philadelphia, PA
$155,000
Cost of living: 9% above average
National Average
$142,000
Philadelphia is $13,000 above
Biotech Software Engineer salary by city
Salary by role in Philadelphia
What you should know
Philadelphia combines a robust healthcare and life sciences sector with established finance and higher education institutions. The city's pharmaceutical corridor is among the strongest in the country. Tech growth has accelerated, particularly in health tech and enterprise software, offering salaries that stretch further than in nearby New York. That is the backdrop for every Biotech Software Engineer offer you will see here.
One thing people overlook: taxes. Pennsylvania has a flat 3.07% state income tax, but Philadelphia adds a 3.75% city wage tax for residents. This combined local burden is worth factoring into salary negotiations. The salary on the offer letter is not the salary in your bank account. Always model your take home before you accept.
On negotiation: Account for the Philadelphia wage tax in your ask. Request a 5 to 8% premium over suburban offers to offset the city's local tax on all earned income. The range for Biotech Software Engineers in Philadelphia runs from $121,000 to $201,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A AI Supply Chain Analyst in Philadelphia earns $154,000 (1% less)
- The highest-paying role in Philadelphia is Principal Quantitative Researcher at $397,000
Common questions.
Biotech Software Engineer salary in other cities
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