Clinical AI Engineer.
Knoxville.
$125,000
median salary, 14% below the national average
$95,000 to $160,000. Last updated April 2026.
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Data points to own the conversation.
The median Clinical AI Engineer salary in Knoxville is $125,000, 14% below the national average. Entry level starts near $95,000. Experienced professionals push past $160,000. Knoxville benefits from the presence of Oak Ridge National Laboratory, the University of Tennessee, and the Tennessee Valley Authority. That spread is your negotiation window.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $113,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$81,000
to $100,000
Mid (3-5 yrs)
$106,000
to $131,000
Senior (6-9 yrs)
$138,000
to $163,000
Lead (10+ yrs)
$156,000
to $194,000
Salary trend
+6% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $28,000 to the total package.
Base
$125,000
Equity
$15,000
Bonus
$10,000
Signing
$3,000
Estimated total: $153,000
How Knoxville compares
Knoxville, TN
$125,000
Cost of living: 11% below average
National Average
$145,000
Knoxville is $20,000 below
Clinical AI Engineer salary by city
Salary by role in Knoxville
What you should know
Before you negotiate a Clinical AI Engineer offer in Knoxville, understand the terrain. Knoxville benefits from the presence of Oak Ridge National Laboratory, the University of Tennessee, and the Tennessee Valley Authority. The national lab drives strong demand for research scientists, engineers, and data analysts. No state income tax and affordable living make it an attractive value proposition. Compensation reflects the specialized intersection of ML engineering and clinical domain expertise. Engineers who can navigate FDA regulatory requirements, build AI systems for clinical decision support, and validate models against clinical outcomes earn premiums. Experience with medical imaging AI, EHR integration, or clinical NLP adds significant value.
Junior clinical AI engineers start at $100,000 to $115,000. Mid-level engineers building FDA-ready AI systems reach $135,000 to $165,000. Senior engineers leading clinical AI programs earn $170,000 to $210,000. Directors of clinical AI at hospital systems or health tech companies can reach $230,000 to $290,000 in total compensation. In Knoxville, your dollars stretch further. Cost of living runs 11% below the national average, which means even a median salary buys a stronger lifestyle.
Base salary is not the full picture. Equity at health AI startups adds $20,000 to $70,000 annually. Bonuses of 10% to 20% are standard. Benefits often include continuing medical education stipends and conference budgets. Some healthcare systems offer pension benefits and loan forgiveness programs. And on the tax side: tennessee has no state income tax on wages. Knoxville has no city income tax. This zero income tax environment combined with very affordable housing creates excellent purchasing power. When someone quotes you $125,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Highlight Oak Ridge National Lab and DOE experience. National lab affiliations and security clearances command significant premiums in the Knoxville area. The range for Clinical AI Engineers in Knoxville runs from $95,000 to $160,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A EdTech Product Manager in Knoxville earns $124,000 (1% less)
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Common questions.
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