Clinical AI Engineer.
Minneapolis.
$148,000
median salary, 2% above the national average
$112,000 to $188,000. Last updated April 2026.
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Data points to own the conversation.
Here is what Clinical AI Engineers actually make in Minneapolis: $112,000 at the 25th percentile, $148,000 at the median, and $188,000 at the 75th. That is 2% above the national average. Minneapolis is a Fortune 500 powerhouse with Target, UnitedHealth Group, Best Buy, and 3M headquartered in the metro. The number on your offer letter will depend on what you bring and how you ask.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $133,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$96,000
to $118,000
Mid (3-5 yrs)
$126,000
to $155,000
Senior (6-9 yrs)
$163,000
to $192,000
Lead (10+ yrs)
$185,000
to $229,000
Salary trend
+6% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $33,000 to the total package.
Base
$148,000
Equity
$18,000
Bonus
$12,000
Signing
$3,000
Estimated total: $181,000
How Minneapolis compares
Minneapolis, MN
$148,000
Cost of living: 5% above average
National Average
$145,000
Minneapolis is $3,000 above
Clinical AI Engineer salary by city
Salary by role in Minneapolis
What you should know
Before you negotiate a Clinical AI Engineer offer in Minneapolis, understand the terrain. Minneapolis is a Fortune 500 powerhouse with Target, UnitedHealth Group, Best Buy, and 3M headquartered in the metro. The city's strong corporate base creates consistent demand across finance, healthcare, retail tech, and supply chain roles. Quality of life is high, and employers offer competitive salaries to offset the cold winters. Compensation reflects the specialized intersection of ML engineering and clinical domain expertise. Engineers who can navigate FDA regulatory requirements, build AI systems for clinical decision support, and validate models against clinical outcomes earn premiums. Experience with medical imaging AI, EHR integration, or clinical NLP adds significant value.
Junior clinical AI engineers start at $100,000 to $115,000. Mid-level engineers building FDA-ready AI systems reach $135,000 to $165,000. Senior engineers leading clinical AI programs earn $170,000 to $210,000. Directors of clinical AI at hospital systems or health tech companies can reach $230,000 to $290,000 in total compensation. In Minneapolis, cost of living sits near the national average, so the numbers you see are roughly what you keep.
Base salary is not the full picture. Equity at health AI startups adds $20,000 to $70,000 annually. Bonuses of 10% to 20% are standard. Benefits often include continuing medical education stipends and conference budgets. Some healthcare systems offer pension benefits and loan forgiveness programs. And on the tax side: minnesota's top income tax rate is 9.85%, one of the highest state rates. There is no city income tax in Minneapolis, but the state burden significantly reduces take home pay. When someone quotes you $148,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Emphasize retention risk when negotiating. Minneapolis employers know that remote opportunities from warmer, lower tax states are a constant competitive threat. The range for Clinical AI Engineers in Minneapolis runs from $112,000 to $188,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A AR/VR Developer in Minneapolis earns $147,000 (1% less)
- The highest-paying role in Minneapolis is Distinguished Engineer at $347,000
Common questions.
Clinical AI Engineer salary in other cities
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