Clinical Research Coordinator.
Chicago.
$68,000
median salary, 6% above the national average
$54,000 to $88,000. Last updated April 2026.
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Data points to own the conversation.
Chicago is 7% more expensive than the national average. For Clinical Research Coordinators, that shakes out to a median of $68,000, with the full range spanning $54,000 to $88,000. Therapeutic area and trial phase drive the biggest pay differences. Know the range before you walk in.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $61,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$44,000
to $54,000
Mid (3-5 yrs)
$58,000
to $71,000
Senior (6-9 yrs)
$75,000
to $88,000
Lead (10+ yrs)
$85,000
to $105,000
Salary trend
+6% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $13,000 to the total package.
Base
$68,000
Equity
$7,000
Bonus
$5,000
Signing
$1,000
Estimated total: $81,000
How Chicago compares
Chicago, IL
$68,000
Cost of living: 7% above average
National Average
$64,000
Chicago is $4,000 above
Clinical Research Coordinator salary by city
Salary by role in Chicago
What you should know
The Clinical Research Coordinator landscape in Chicago is not what most salary sites will tell you. Chicago's economy is anchored by finance, manufacturing, and a rapidly expanding tech sector. The city has become a major hub for fintech, enterprise SaaS, and e-commerce. With lower living costs than coastal cities and a deep talent pool from top universities, Chicago offers strong salary to cost of living ratios for professionals across industries. Therapeutic area and trial phase drive the biggest pay differences. Oncology, gene therapy, and Phase I trials pay the most due to protocol complexity. ACRP or SoCRA certification adds 8 to 12% above non-certified coordinators. Academic medical centers and large CROs in biotech hubs offer the highest salaries.
Entry-level CRCs start at $48,000 to $55,000 with a science degree. Certified CRCs with three to five years of experience earn $65,000 to $80,000. Senior CRCs or clinical research managers can reach $85,000 to $110,000 overseeing multi-site trials and regulatory submissions. In Chicago, cost of living sits near the national average, so the numbers you see are roughly what you keep.
Base salary is not the full picture. CRCs receive benefits including tuition reimbursement, certification exam fees, and conference attendance stipends. CRO-employed coordinators may receive project completion bonuses of $2,000 to $5,000. Some pharmaceutical sponsors offer annual merit increases of 3 to 6%. And on the tax side: illinois has a flat 4.95% state income tax. Chicago does not levy a separate city income tax, making the overall burden moderate compared to coastal metros. When someone quotes you $68,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Reference the Bay Area or NYC salary band for your role, then negotiate a modest discount. Chicago employers routinely offer 85 to 90% of coastal pay. The range for Clinical Research Coordinators in Chicago runs from $54,000 to $88,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
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Common questions.
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Other salaries in Chicago
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