Clinical Research Coordinator.
San Antonio.
$58,000
median salary, 9% below the national average
$45,000 to $74,000. Last updated April 2026.
Get the job.
Data points to own the conversation.
If you are evaluating a Clinical Research Coordinator offer in San Antonio, TX, here is the reality: $45,000 to $74,000, with $58,000 as the midpoint. 9% below the national average. Therapeutic area and trial phase drive the biggest pay differences. Do not accept the first number.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $52,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$38,000
to $46,000
Mid (3-5 yrs)
$49,000
to $61,000
Senior (6-9 yrs)
$64,000
to $75,000
Lead (10+ yrs)
$73,000
to $90,000
Salary trend
+7% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $11,000 to the total package.
Base
$58,000
Equity
$6,000
Bonus
$4,000
Signing
$1,000
Estimated total: $69,000
How San Antonio compares
San Antonio, TX
$58,000
Cost of living: 9% below average
National Average
$64,000
San Antonio is $6,000 below
Clinical Research Coordinator salary by city
Salary by role in San Antonio
What you should know
The Clinical Research Coordinator landscape in San Antonio is not what most salary sites will tell you. San Antonio has a major military presence with Joint Base San Antonio and a growing cybersecurity hub. The city is home to USAA headquarters and a cluster of healthcare systems. The extremely affordable cost of living and no state income tax make it attractive for professionals seeking purchasing power. Therapeutic area and trial phase drive the biggest pay differences. Oncology, gene therapy, and Phase I trials pay the most due to protocol complexity. ACRP or SoCRA certification adds 8 to 12% above non-certified coordinators. Academic medical centers and large CROs in biotech hubs offer the highest salaries.
Entry-level CRCs start at $48,000 to $55,000 with a science degree. Certified CRCs with three to five years of experience earn $65,000 to $80,000. Senior CRCs or clinical research managers can reach $85,000 to $110,000 overseeing multi-site trials and regulatory submissions. In San Antonio, cost of living sits near the national average, so the numbers you see are roughly what you keep.
Base salary is not the full picture. CRCs receive benefits including tuition reimbursement, certification exam fees, and conference attendance stipends. CRO-employed coordinators may receive project completion bonuses of $2,000 to $5,000. Some pharmaceutical sponsors offer annual merit increases of 3 to 6%. And on the tax side: texas has no state income tax. San Antonio has no city income tax. The zero tax environment and very affordable housing create exceptional purchasing power relative to most metros. When someone quotes you $58,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Leverage the cybersecurity corridor. San Antonio's NSA facility and military cyber operations drive demand for cleared security professionals at premium rates. The range for Clinical Research Coordinators in San Antonio runs from $45,000 to $74,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A Ironworker in San Antonio earns $57,000 (2% less)
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Common questions.
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