Lead Healthcare Interoperability Engineer Salary.
Across 81 U.S. cities.
$169,000
national median salary
$132,000 to $219,000. Last updated April 2026.
Highest Paying
$230,000
San Francisco, CA
Best Purchasing Power
$176,000
Anchorage, AK
Lowest Paying
$127,000
Charleston, WV
Salary data sourced from SEC filings, H-1B Labor Condition Applications (DOL), Bureau of Labor Statistics Occupational Employment and Wage Statistics, and aggregated job postings across 50+ platforms. Ranges reflect 25th to 75th percentile for full-time positions. Cost-of-living adjustments use Bureau of Economic Analysis Regional Price Parities (2025 index). Last updated April 2026. Baseline derived from BLS SOC 29-9021. Full methodology.
The average Lead Healthcare Interoperability Engineer salary in the United States is $169,000 in 2026, with the full range spanning $132,000 at the 25th percentile to $219,000 at the 75th. San Francisco pays the most at $230,000, while Anchorage offers the best purchasing power after cost-of-living adjustments. Compensation for Lead Healthcare Interoperability Engineers is driven by depth of technical specialization, open-source or published work, and the specific technology stack.
Lead Healthcare Interoperability Engineer salary by city
Skills that increase Lead Healthcare Interoperability Engineer pay
The skills below command measurable salary premiums for Lead Healthcare Interoperability Engineers based on job posting data. Learning the top skill here could add $23,660 to your annual compensation.
≈ +$23,660 per year
≈ +$21,970 per year
≈ +$20,280 per year
≈ +$18,590 per year
≈ +$18,590 per year
≈ +$16,900 per year
≈ +$16,900 per year
≈ +$15,210 per year
What you should know
Compensation for Lead Healthcare Interoperability Engineers is driven by depth of technical specialization, open-source or published work, and the specific technology stack. Base salary carries most of the total compensation, with bonuses adding roughly 10% in a typical year. Within clinical practice, specialty (primary care vs subspecialty vs surgical) and practice setting drive the largest compensation variance.
Lead Healthcare Interoperability Engineers typically advance from entry to senior over 5 to 8 years, with staff and principal levels requiring 10+ years and demonstrated cross-team impact. For Lead Healthcare Interoperability Engineers specifically, the seniority anchor typically means 7 to 12 years of experience with demonstrated independent scope.
Total compensation for Lead Healthcare Interoperability Engineers runs roughly $186K at median when factoring base + typical bonus (~10% of base). Base salary carries most of the compensation; benefits (healthcare, 401(k) match, PTO) add an estimated 15–25% in imputed value on top. In clinical practice, shift differentials, call pay, and production-based bonuses can add 20–40% to base — the structure varies significantly by specialty and setting.
Total compensation breakdown
Salary by company size
Remote salary adjustment
Remote Lead Healthcare Interoperability Engineers typically earn $152,000 (10% less than on-site). This reflects location-adjusted pay policies at companies using geographic salary bands. Some companies pay flat national rates regardless of location.
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