Machine Learning Engineer.
St. Louis.
$142,000
median salary, 8% below the national average
$110,000 to $184,000. Last updated April 2026.
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Data points to own the conversation.
St. Louis is 10% cheaper than the national average. For Machine Learning Engineers, that shakes out to a median of $142,000, with the full range spanning $110,000 to $184,000. Production ML experience, deep learning framework fluency, and ability to optimize models for scale are the strongest differentiators. Know the range before you walk in.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $128,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$92,000
to $114,000
Mid (3-5 yrs)
$121,000
to $149,000
Senior (6-9 yrs)
$156,000
to $185,000
Lead (10+ yrs)
$178,000
to $220,000
Salary trend
+9% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $63,000 to the total package.
Base
$142,000
Equity
$38,000
Bonus
$16,000
Signing
$9,000
Estimated total: $205,000
Machine Learning Engineer salary by company
Total compensation estimates include base, equity, bonus, and signing. Ranges reflect mid to senior level. Derived from public H-1B LCA filings, SEC proxy statements, and aggregated self-reported data.
How St. Louis compares
St. Louis, MO
$142,000
Cost of living: 10% below average
National Average
$155,000
St. Louis is $13,000 below
Machine Learning Engineer salary by city
Salary by role in St. Louis
What you should know
The Machine Learning Engineer landscape in St. Louis is not what most salary sites will tell you. St. Louis offers one of the most affordable major metro areas in the country, with a strong base in healthcare, financial services, and manufacturing. The region's anchor employers include Boeing, Centene, and Washington University's medical campus. A growing biotech and plant sciences corridor centered on the Cortex Innovation District is attracting new investment and talent. Production ML experience, deep learning framework fluency, and ability to optimize models for scale are the strongest differentiators. Engineers who bridge research and production by deploying models that serve millions of predictions per day command significant premiums. Specialization in recommendation systems, search ranking, or fraud detection adds further value.
Entry level ML engineers start at $110,000 to $140,000, reaching mid level at $145,000 to $190,000 in two to three years. Senior ML engineers earn $190,000 to $260,000. Staff ML engineers at top companies exceed $350,000 in total compensation, with research oriented roles paying even more. In St. Louis, cost of living sits near the national average, so the numbers you see are roughly what you keep.
Base salary is not the full picture. Equity at AI focused companies adds $30,000 to $150,000+ annually. Bonuses of 10 to 20% are standard. Signing bonuses of $25,000 to $75,000 are common at well funded firms. Benefits frequently include GPU compute budgets, conference sponsorship, and research publication support. And on the tax side: missouri's top income tax rate is about 4.8%, and St. Louis City adds a 1% earnings tax. The low base cost of living means your after tax salary still stretches further than in most metros. When someone quotes you $142,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Emphasize your willingness to work in person at Cortex or the BJC campus. St. Louis employers offer higher packages for candidates who commit to the local innovation hubs. The range for Machine Learning Engineers in St. Louis runs from $110,000 to $184,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A Healthcare AI Integrator in St. Louis earns $143,000 (1% more)
- The highest-paying role in St. Louis is Chief AI Officer at $276,000
Common questions.
Machine Learning Engineer salary in other cities
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