Medical Assistant.
Knoxville.
$33,000
median salary, 13% below the national average
$28,000 to $40,000. Last updated April 2026.
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Data points to own the conversation.
If you are evaluating a Medical Assistant offer in Knoxville, TN, here is the reality: $28,000 to $40,000, with $33,000 as the midpoint. 13% below the national average. Certification status is the largest pay differentiator, with CMA and RMA credentials adding 10 to 15% over uncertified MAs. Do not accept the first number.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $30,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$21,000
to $26,000
Mid (3-5 yrs)
$28,000
to $35,000
Senior (6-9 yrs)
$36,000
to $43,000
Lead (10+ yrs)
$41,000
to $51,000
Salary trend
+3% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $7,000 to the total package.
Base
$33,000
Equity
$4,000
Bonus
$2,000
Signing
$1,000
Estimated total: $40,000
How Knoxville compares
Knoxville, TN
$33,000
Cost of living: 11% below average
National Average
$38,000
Knoxville is $5,000 below
Medical Assistant salary by city
Salary by role in Knoxville
What you should know
The Medical Assistant landscape in Knoxville is not what most salary sites will tell you. Knoxville benefits from the presence of Oak Ridge National Laboratory, the University of Tennessee, and the Tennessee Valley Authority. The national lab drives strong demand for research scientists, engineers, and data analysts. No state income tax and affordable living make it an attractive value proposition. Certification status is the largest pay differentiator, with CMA and RMA credentials adding 10 to 15% over uncertified MAs. Specialty practices like dermatology, orthopedics, and cardiology pay more than general primary care. Urban areas and hospital-owned practices consistently offer higher wages than rural independent clinics.
Entry-level MAs start at $30,000 to $34,000 without certification. Certified MAs with three to five years of experience earn $38,000 to $44,000. Lead MAs or clinical supervisors overseeing support staff can reach $46,000 to $55,000 in larger practices or health systems. In Knoxville, your dollars stretch further. Cost of living runs 11% below the national average, which means even a median salary buys a stronger lifestyle.
Base salary is not the full picture. Medical assistants typically receive health insurance, paid time off, and retirement plan access. Some employers offer tuition assistance for nursing or allied health programs, which adds long-term value beyond the base salary. And on the tax side: tennessee has no state income tax on wages. Knoxville has no city income tax. This zero income tax environment combined with very affordable housing creates excellent purchasing power. When someone quotes you $33,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Highlight Oak Ridge National Lab and DOE experience. National lab affiliations and security clearances command significant premiums in the Knoxville area. The range for Medical Assistants in Knoxville runs from $28,000 to $40,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A Pharmacy Technician in Knoxville earns $32,000 (3% less)
- The highest-paying role in Knoxville is Distinguished Engineer at $305,000
Common questions.
Medical Assistant salary in other cities
Other salaries in Knoxville
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