AI Protein Structure Specialist Salary.
Across 81 U.S. cities.
$220,000
national median salary
$172,000 to $286,000. Last updated July 2026.
Highest Paying
$306,000
San Francisco, CA
Best Purchasing Power
$229,000
Minneapolis, MN
Lowest Paying
$168,000
Charleston, WV
Salary data sourced from Bureau of Labor Statistics Occupational Employment and Wage Statistics, H-1B Labor Condition Applications (DOL), state pay-transparency job postings, and community submissions. Most ranges are anchored to BLS OES occupation wage percentiles and placed by seniority level (entry near the 25th, mid at the median, senior at the 75th); a minority of emerging roles retain a modeled estimate where BLS has no matching series. Cost-of-living adjustments use Bureau of Economic Analysis Regional Price Parities (2025 index). Last updated July 2026. Baseline derived from BLS SOC 19-1021. Full methodology.
The average AI Protein Structure Specialist salary in the United States is $220,000 in 2026, with the full range spanning $172,000 at the 25th percentile to $286,000 at the 75th. San Francisco pays the most at $306,000, while Minneapolis offers the best purchasing power after cost-of-living adjustments. Model complexity, data pipeline scale, and infrastructure cost optimization are the primary drivers.
AI Protein Structure Specialist salary by city.
Skills that increase AI Protein Structure Specialist pay.
The skills below command measurable salary premiums for AI Protein Structure Specialists based on job posting data. Learning the top skill here could add $30,800 to your annual compensation.
≈ +$30,800 per year
≈ +$28,600 per year
≈ +$26,400 per year
≈ +$24,200 per year
≈ +$22,000 per year
≈ +$22,000 per year
≈ +$22,000 per year
≈ +$19,800 per year
What you should know.
Model complexity, data pipeline scale, and infrastructure cost optimization are the primary drivers. AI Protein Structure Specialists with experience across the full ML lifecycle, from research prototyping to production serving, earn more than those focused on a single phase. Domain expertise in high-stakes verticals like healthcare, finance, or autonomous systems adds measurable premiums.
Entry-level AI Protein Structure Specialists start near $172,000. Mid-career professionals with three to five years of experience reach $220,000 to $286,000. Senior-level roles command $282,000 to $341,000. Management transitions to director-level positions offer $363,000 and above.
Equity at top-tier companies adds 30% to 60% above base salary. Annual bonuses of 15% to 25% are standard. Signing bonuses of $25,000 to $75,000 are common when changing roles. Refresher equity grants vest annually. Relocation packages and executive benefits like financial planning are typical.
Total compensation breakdown.
Salary by company size
Remote salary adjustment
Remote AI Protein Structure Specialists typically earn $205,000 (7% less than on-site). This reflects location-adjusted pay policies at companies using geographic salary bands. Some companies pay flat national rates regardless of location.
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Common questions about AI Protein Structure Specialist pay.
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