Physician Assistant.
San Diego.
$138,000
median salary, 17% above the national average
$119,000 to $161,000. Last updated April 2026.
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Data points to own the conversation.
Physician Assistant pay in San Diego ranges from $119,000 to $161,000 in 2026. The median is $138,000, 17% above the national average. San Diego's economy thrives on defense, biotech, and a growing tech startup scene. Every dollar in that range is negotiable if you come prepared.
Salary range
Where do you fall?
Salary by experience
The gap between entry and lead level is typically $124,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$90,000
to $110,000
Mid (3-5 yrs)
$117,000
to $145,000
Senior (6-9 yrs)
$152,000
to $179,000
Lead (10+ yrs)
$173,000
to $214,000
Salary trend
+7% YoYTotal compensation
Base salary is not the full picture. Equity, bonus, and signing can add $37,000 to the total package.
Base
$138,000
Equity
$21,000
Bonus
$13,000
Signing
$3,000
Estimated total: $175,000
How San Diego compares
San Diego, CA
$138,000
Cost of living: 17% above average
National Average
$118,000
San Diego is $20,000 above
Physician Assistant salary by city
Salary by role in San Diego
What you should know
Before you negotiate a Physician Assistant offer in San Diego, understand the terrain. San Diego's economy thrives on defense, biotech, and a growing tech startup scene. The city's proximity to major military installations drives strong aerospace and cybersecurity demand. Biotech companies along the Torrey Pines corridor compete aggressively for scientific and engineering talent, pushing specialized salaries close to Bay Area levels. Surgical subspecialties and emergency medicine pay the highest PA salaries, often 20 to 30% above primary care. Geographic location matters significantly, with rural and underserved areas offering premium pay to attract talent. Experience in procedural skills and first-assist certification further boost compensation.
Entry-level PAs earn $95,000 to $105,000 in their first role. Mid-career PAs with specialty experience reach $120,000 to $135,000. Senior PAs in surgical specialties or leadership positions can command $145,000 to $165,000 with additional administrative responsibilities. In San Diego, those numbers run higher. The cost of living here is 17% above average, and employers adjust to compete.
Base salary is not the full picture. PAs commonly receive productivity bonuses, CME allowances of $2,000 to $5,000 annually, malpractice insurance, and relocation assistance. Hospital systems often add shift differentials for nights, weekends, and call coverage. And on the tax side: california's top 13.3% state tax applies here. While San Diego has no city income tax, the state burden means you should negotiate gross pay higher than you might expect for the cost of living. When someone quotes you $138,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Leverage defense and biotech sector demand. Candidates with security clearances or specialized science backgrounds can command 15 to 20% premiums in San Diego. The range for Physician Assistants in San Diego runs from $119,000 to $161,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: SEC filings, H-1B LCA (DOL), BLS OES, 50+ job posting platforms. COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified April 8, 2026. Full methodology
Considering a related role?
- A Nurse Practitioner in San Diego earns $139,000 (1% more)
- The highest-paying role in San Diego is Chief AI Officer at $370,000
Common questions.
Physician Assistant salary in other cities
Other salaries in San Diego
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